Hypothermia is not therapeutic in a neonatal piglet model of inflammation-sensitized hypoxia–ischemia

Volume: 91, Issue: 6, Pages: 1416 - 1427
Published: May 28, 2021
Abstract
Background Perinatal inflammation combined with hypoxia–ischemia (HI) exacerbates injury in the developing brain. Therapeutic hypothermia (HT) is standard care for neonatal encephalopathy; however, its benefit in inflammation-sensitized HI (IS-HI) is unknown. Methods Twelve newborn piglets received a 2 µg/kg bolus and 1 µg/kg/h infusion over 52 h of Escherichia coli lipopolysaccharide (LPS). HI was induced 4 h after LPS bolus. After HI, piglets...
Paper Details
Title
Hypothermia is not therapeutic in a neonatal piglet model of inflammation-sensitized hypoxia–ischemia
Published Date
May 28, 2021
Volume
91
Issue
6
Pages
1416 - 1427
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