Acute Ataxia and Paresthesia in a Healthy 5-year-old Girl.

Published on Jun 1, 2021in Pediatrics in Review
· DOI :10.1542/PIR.2020-0007
Richard J Taylor , David M Ritter (University of Cincinnati Academic Health Center)+ 1 AuthorsMatthew W. Zackoff (University of Cincinnati Academic Health Center)
#1Feenalie Patel (UTHSC: University of Tennessee Health Science Center)
#2Ashley Kiefer (UTHSC: University of Tennessee Health Science Center)H-Index: 3
Last. Bindiya Bagga (UTHSC: University of Tennessee Health Science Center)H-Index: 3
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1 CitationsSource
#1Muhammad Morshed (UBC: University of British Columbia)H-Index: 27
#2Lisa Li (UBC: University of British Columbia)H-Index: 1
Last. Quantine Wong (Emerging Pathogens Institute)H-Index: 1
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Abstract Background: Tick paralysis is a frequently overlooked severe disease characterized by bilateral ascending flaccid paralysis caused by a neurotoxin produced by feeding ticks. We aimed to characterize suspected tick paralysis cases documented at the BC Centre for Disease Control (BCCDC) in British Columbia (BC) from 1993 to 2016 and reviewed prevention, diagnosis, and treatment considerations. Methods: Demographic, geographic, and clinical data from test requisition forms for ticks submit...
11 CitationsSource
#1Chong Han Pek (University Health System)H-Index: 5
#2Crystal Shuk Jin Cheong (University Health System)H-Index: 3
Last. Jane Lim (University Health System)H-Index: 3
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Abstract Background Ticks are blood-sucking arachnids that feed on all classes of vertebrates, including humans. Ixodes holocyclus , also known as the Australian Paralysis Tick, is capable of causing a myriad of clinical issues in humans and companion animals, including the transmission of infectious agents, toxin-mediated paralysis, allergic and inflammatory reactions, and mammalian meat allergies in humans. The Australian Paralysis Tick is endemic to Australia, and only two other exported case...
7 CitationsSource
#1Olga D. Taraschenko (Albany Medical College)H-Index: 8
#1Olga Taraschenko (UNMC: University of Nebraska Medical Center)H-Index: 4
Last. Karen M. Powers (Albany Medical College)H-Index: 1
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Abstract Background Tick paralysis is an arthropod-transmitted disease causing potentially lethal progressive ascending weakness. The presenting symptoms of tick paralysis overlap those of acute inflammatory diseases of the peripheral nervous system and spinal cord; thus, the condition is often misdiagnosed, leading to unnecessary treatments and prolonged hospitalization. Patient A 2-year-old girl residing in northern New York and having no history of travel to areas endemic to ticks presented w...
5 CitationsSource
#1Jonathan A. Edlow (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 33
Tick paralysis is a toxin-mediated cause of acute flaccid paralysis. Most practitioners will go through their entire career without ever encountering a case. An important veterinary disease, tick paralysis is rare in humans. Although it has certain geographical proclivities, it exists worldwide. Although it tends to occur in young girls, it can occur in any age group. Due to its rarity, doctors often forget to consider tick paralysis in the differential diagnosis of the weak patient. Therefore i...
54 CitationsSource
Tick paralysis (TP) is a neurotoxic poisoning primarily afflicting young girls in endemic regions. Recent case series of TP have described increasing misdiagnoses of TP as the Guillain–Barre syndrome (GBS). A meta-analysis of the scientific literature was conducted using Internet search engines to assess the evolving epidemiology of TP. Fifty well-documented cases of TP were analyzed over the period 1946–2006. Cases were stratified by demographics, clinical manifestations, and outcomes. Misdiagn...
30 CitationsSource
#1Michael W. Felz (Georgia Regents University)H-Index: 11
#2Carrie Davis Smith (Georgia Regents University)H-Index: 1
Last. Thomas Robert SwiftH-Index: 1
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Tick paralysis is a neurologic syndrome that is frequently confused with other acute disorders. In this syndrome, ascending paralysis is caused by a potent neurotoxin produced by an attached, engorged tick. Removal of the tick leads to prompt recovery. Although cases of tick paralysis were clearly described almost 90 years ago in the United States,1 Canada,2 and Australia,3 the syndrome is unfamiliar to many clinicians today. Since a delay in the diagnosis can have devastating consequences, phys...
66 CitationsSource
The Australian scrub-tick Ixodes holocyclus causes a series of significant toxic effects in its victims. The most important feature of tick envenomation is neuromuscular paralysis. Children poisoned by ticks may manifest only local motoneural effects, usually facial paralysis. Progressive ascending flaccid paralysis occurs if the removal of an embedded tick is delayed. The specific neurological features of tick-bite are discussed in the light of a series of 6 children who all showed signs of tic...
36 CitationsSource
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