Reply to the letter regarding "Contribution of PET imaging to radiotherapy planning and monitoring in glioma patients-a report of the PET/RANO group": 18F-fluciclovine and target volume delineation.

Published on Jun 3, 2021in Neuro-oncology10.247
· DOI :10.1093/NEUONC/NOAB098
Norbert Galldiks46
Estimated H-index: 46
(Forschungszentrum Jülich),
Maximilian Niyazi30
Estimated H-index: 30
(LMU: Ludwig Maximilian University of Munich)
+ 1 AuthorsKarl-Josef Langen60
Estimated H-index: 60
(Forschungszentrum Jülich)
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6 Authors (Rupesh Kotecha, ..., Samuel T. Chao)
111 Citations
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#1Norbert Galldiks (University of Cologne)H-Index: 46
#2Maximilian Niyazi (LMU: Ludwig Maximilian University of Munich)H-Index: 30
Last. Jörg-Christian Tonn (LMU: Ludwig Maximilian University of Munich)H-Index: 60
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The management of patients with glioma usually requires multimodality treatment including surgery, radiotherapy, and systemic therapy. Accurate neuroimaging plays a central role for radiotherapy planning and follow-up after radiotherapy completion. In order to maximize the radiation dose to the tumor and to minimize toxic effects on the surrounding brain parenchyma, reliable identification of tumor extent and target volume delineation is crucial. The use of PET for radiotherapy planning and moni...
2 CitationsSource
#1Flóra John (WSU: Wayne State University)H-Index: 3
#2Otto Muzik (WSU: Wayne State University)H-Index: 73
Last. Csaba JuhászH-Index: 59
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Due to its metabolism via the serotonin and kynurenine pathways, tryptophan plays a key role in multiple disease processes including cancer. Imaging tryptophan uptake and metabolism in vivo can be achieved with tryptophan derivative positron emission tomography (PET) radiotracers. While human studies with such tracers have been confined to C-11-labeled compounds, preclinical development of F-18-labeled tryptophan-based radiotracers has surged in recent years. We performed a systematic review of ...
3 CitationsSource
#1Laure Michaud (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 5
#2Brad Beattie (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 11
Last. Ronald G. Blasberg (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 79
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Purpose The aim of our study was to investigate the efficacy of 18F-Fluciclovine brain PET imaging in recurrent gliomas, and to compare the utility of these images to that of contrast enhanced magnetic resonance imaging (MRI) and to [11C-methyl]-L-methionine (11C-Methionine) PET imaging. We also sought to gain insight into the factors affecting the uptake of 18F-FACBC in both tumors and normal brain, and specifically to evaluate how the uptake in these tissues varied over an extended period of t...
9 CitationsSource
Last. Live EikenesH-Index: 17
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PurposeThis pilot study aimed to evaluate the amino acid tracer 18F-FACBC with simultaneous PET/MRI in diagnostic assessment and neurosurgery of gliomas.Materials and MethodsEleven patients with suspected primary or recurrent low- or high-grade glioma received an 18F-FACBC PET/MRI examination before
5 CitationsSource
#1Naohiro Tsuyuguchi (OCU: Osaka City University)H-Index: 22
#2Yuzo Terakawa (Memorial Hospital of South Bend)H-Index: 11
Last. Yonehiro KanemuraH-Index: 27
view all 5 authors...
Objective(s): 18F-fluciclovine (trans-1-amino-3-18F fluorocyclobutanecarboxylic acid, FACBC) is an artificial amino acid radiotracer used for positron emission tomography (PET) studies, which is metabolically stable in vivo and has a long half-life. It has already been shown that FACBC-PET is useful for glioma imaging. However, there have been no reports evaluating the efficiency of FACBC-PET in the diagnosis of brain tumors in comparison with other PET tracers in clinical studies. The purpose o...
15 CitationsSource
#1Keishi Horiguchi (Gunma University)H-Index: 9
#2Masahiko Tosaka (Gunma University)H-Index: 18
Last. Yuhei Yoshimoto (Gunma University)H-Index: 19
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Background We investigated the relationship between metabolic activity and histological features of gliomas using fluorine-18α-methyltyrosine (18F-FAMT) positron emission tomography (PET) compared with fluorine-18 fluorodeoxyglucose (18F-FDG) PET in 38 consecutive glioma patients. The tumor to normal brain ratios (T/N ratios) were calculated, and the relationships between T/N ratio and World Health Organization tumor grade or MIB-1 labeling index were evaluated. The diagnostic values of T/N rati...
3 CitationsSource
#1Toshihiko Wakabayashi (Nagoya University)H-Index: 53
#2Toshihiko IuchiH-Index: 17
Last. Kan KubomuraH-Index: 1
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Objective(s): The study objective was to assess the diagnostic performance of positron emission tomography (PET) for gliomas using the novel tracer 18F-fluciclovine (anti-18FFACBC) and to evaluate the safety of this tracer in patients with clinically suspected gliomas.Methods: Anti-18FFACBC was administered to 40 patients with clinically suspected high- or low-grade gliomas, followed by PET imaging. T1-weighted, contrast-enhanced T1-weighted, and fluid-attenuated inversion recovery (or T2-weight...
15 CitationsSource
#1Akihide Kondo (Juntendo University)H-Index: 9
#2Hisato Ishii (Juntendo University)H-Index: 9
Last. Hajime Arai (Juntendo University)H-Index: 35
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Objective [18F]Fluciclovine (anti-[18F]FACBC) has demonstrated diagnostic efficacy for cancers of the brain where [18F]fludeoxyglucose has limitations. We conducted a phase IIa study of anti-[18F]FACBC to assess its accumulation pattern and safety in patients with malignant glioma.
32 CitationsSource
#1David M. Schuster (Emory University)H-Index: 33
#2John R. VotawH-Index: 50
Last. Mark M. GoodmanH-Index: 50
view all 9 authors...
Conventional imaging techniques have serious limitations in the detection, staging, and restaging of prostate carcinoma. Anti1-amino-3-18F-fluorocyclobutane-1-carboxylicacid(anti-18F-FACBC) is a synthetic L-leucine analog that has excellent in vitro uptake within the DU-145 prostate carcinoma cell line and orthotopically implanted prostate tumor in nude rats. There is little renal excretion compared with 18 F-FDG. The present study examines anti- 18 F-FACBC uptake in patients with newly diagnose...
312 Citations
#1Timothy M. Shoup (Emory University)H-Index: 24
#2Jeffrey J. OlsonH-Index: 68
Last. Mark M. Goodman (Emory University)H-Index: 50
view all 10 authors...
We have developed a new tumor-avid amino acid, 1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC), labeled with 18 F for nuclear medicine imaging. Methods: [ 18 F]FACBC was prepared with high specific activity (no carrier added [NCA]) and was evaluated for its potential in tumor localization. A comparative study was performed for [ 18 F]FACBC and [ 18 F]]2-fluorodeoxyglucose (FDG) in which the uptake of each agent in 9L gliosarcoma (implanted intracerebrally in Fisher 344 rats) was measured. ...
136 Citations
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