Mitochondrial DNA variation and cancer
Abstract
Variation in the mitochondrial DNA (mtDNA) sequence is common in certain tumours. Two classes of cancer mtDNA variants can be identified: de novo mutations that act as 'inducers' of carcinogenesis and functional variants that act as 'adaptors', permitting cancer cells to thrive in different environments. These mtDNA variants have three origins: inherited variants, which run in families, somatic mutations arising within each cell or individual,...
Paper Details
Title
Mitochondrial DNA variation and cancer
Published Date
May 27, 2021
Journal
Volume
21
Issue
7
Pages
431 - 445
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