N-terminal tail prolines of Gal-3 mediate its oligomerization/phase separation

Galectins are a class of proteins that bind to β-galactose–containing glycoconjugates and play critical roles in developmental, homeostatic, and pathological contexts (1, 2). Expressed across animal tissues, galectins are synthesized in the cytoplasm and trafficked to the extracellular milieu via the unconventional secretion pathway, although they may also be localized within the cytoplasm and nuclei of cells (3). Secreted galectins bind to cell...