Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5

Science56.90
Volume: 372, Issue: 6546, Pages: 1085 - 1091
Published: Jun 4, 2021
Abstract
Whereas coding variants often have pleiotropic effects across multiple tissues, noncoding variants are thought to mediate their phenotypic effects by specific tissue and temporal regulation of gene expression. Here, we investigated the genetic and functional architecture of a genomic region within the FTO gene that is strongly associated with obesity risk. We show that multiple variants on a common haplotype modify the regulatory properties of...
Paper Details
Title
Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5
Published Date
Jun 4, 2021
Journal
Volume
372
Issue
6546
Pages
1085 - 1091
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