Texture Analysis of Fractional Water Content Images Acquired during PET/MRI: Initial Evidence for an Association with Total Lesion Glycolysis, Survival and Gene Mutation Profile in Primary Colorectal Cancer.

Published on May 31, 2021in Cancers6.126
· DOI :10.3390/CANCERS13112715
Balaji Ganeshan32
Estimated H-index: 32
(UCL: University College London),
Kenneth A. Miles56
Estimated H-index: 56
(UCL: University College London)
+ 17 AuthorsAshley M. Groves48
Estimated H-index: 48
(UCL: University College London)
Source
Abstract
To assess the capability of fractional water content (FWC) texture analysis (TA) to generate biologically relevant information from routine PET/MRI acquisitions for colorectal cancer (CRC) patients. Thirty consecutive primary CRC patients (mean age 63.9, range 42-83 years) prospectively underwent FDG-PET/MRI. FWC tumor parametric images generated from Dixon MR sequences underwent TA using commercially available research software (TexRAD). Data analysis comprised (1) identification of functional imaging correlates for texture features (TF) with low inter-observer variability (intraclass correlation coefficient: ICC > 0.75), (2) evaluation of prognostic performance for FWC-TF, and (3) correlation of prognostic imaging signatures with gene mutation (GM) profile. Of 32 FWC-TF with ICC > 0.75, 18 correlated with total lesion glycolysis (TLG, highest: rs = -0.547, p = 0.002). Using optimized cut-off values, five MR FWC-TF identified a good prognostic group with zero mortality (lowest: p = 0.017). For the most statistically significant prognostic marker, favorable prognosis was significantly associated with a higher number of GM per patient (medians: 7 vs. 1.5, p = 0.009). FWC-TA derived from routine PET/MRI Dixon acquisitions shows good inter-operator agreement, generates biological relevant information related to TLG, GM count, and provides prognostic information that can unlock new clinical applications for CRC patients.
Download
References56
Newest
#1Francesco Alessandrino (Harvard University)H-Index: 13
#2Rahul Gujrathi (Harvard University)H-Index: 4
Last. Atul B. Shinagare (Harvard University)H-Index: 28
view all 8 authors...
Abstract Background Reliable biomarkers to predict the response of metastatic urothelial cancer (mUC) to programmed death-1 and programmed death-ligand 1 (PD-1/PD-L1) inhibitors are being investigated. Texture analysis represents tumor heterogeneity and may serve as a predictor of response in mUC. Objective To assess the predictive ability of computed tomography (CT) texture analysis for progression-free survival (PFS) in patients with mUC treated with PD-1/PD-L1 inhibitors. Design, setting, and...
8 CitationsSource
#1Paul Riviere (University of California, Berkeley)H-Index: 1
#1Paul Riviere (UCSD: University of California, San Diego)H-Index: 1
Last. Razelle Kurzrock (UCSD: University of California, San Diego)H-Index: 133
view all 14 authors...
Higher tumor mutational burden (TMB) has been correlated with response to checkpoint blockade immunotherapy. However, it is unclear whether TMB independently serves as a prognostic biomarker for outcomes in immunotherapy-naive patients. Here we evaluated the relationship between TMB and overall survival in 1,415 immunotherapy-naive patients with diverse advanced malignancies. TMB was studied both as a tiered variable (low ≤5 mutations/Mb, intermediate >5 and
10 CitationsSource
#1George Coukos (Ludwig Institute for Cancer Research)H-Index: 93
Neoadjuvant checkpoint blockade achieves deep or complete pathologic responses in patients with mismatch-repair-deficient and mismatch-repair-proficient early colon cancer.
3 CitationsSource
#1Marco Ravanelli (University of Brescia)H-Index: 13
#2Giorgio Maria Agazzi (University of Brescia)H-Index: 6
Last. Davide Farina (University of Brescia)H-Index: 23
view all 16 authors...
Abstract Purpose The aim of this study was to assess computed-tomography histogram analysis (CTHA) as prognostic and predictive factor in platinum-refractory non-small cell lung carcinoma (NSCLC) treated with immune checkpoint inhibitor Nivolumab. Method One hundred and four patients were enrolled from 3 different centers. CT was performed using similar parameters among different scanners. CTHA was performed with the proprietary software TexRAD, which extracts histogram features at different spa...
4 CitationsSource
#1J. Ferlay (IARC: International Agency for Research on Cancer)H-Index: 18
#2Murielle Colombet (IARC: International Agency for Research on Cancer)H-Index: 8
Last. Freddie Bray (IARC: International Agency for Research on Cancer)H-Index: 18
view all 8 authors...
: Estimates of the worldwide incidence and mortality from 36 cancers and for all cancers combined for the year 2018 are now available in the GLOBOCAN 2018 database, compiled and disseminated by the International Agency for Research on Cancer (IARC). This paper reviews the sources and methods used in compiling the cancer statistics in 185 countries. The validity of the national estimates depends upon the representativeness of the source information, and to take into account possible sources of bi...
2,344 CitationsSource
#1Martin Lewis (UCL: University College London)H-Index: 3
#2Balaji Ganeshan (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 1
Last. Stefanie Thust (UCL Institute of Neurology)H-Index: 7
view all 9 authors...
Abstract Background: To determine if filtration-histogram based texture analysis (MRTA) of clinical MR imaging can non-invasively identify molecular subtypes of untreated gliomas. Methods: Post Gadolinium T1-weighted (T1+Gad) images, T2-weighted (T2) images and apparent diffusion coefficient (ADC) maps of 97 gliomas (54 = WHO II, 20 = WHO III, 23 = WHO IV) between 2010 and 2016 were studied. Whole-tumor segmentations were performed on a proprietary texture analysis research platform (TexRAD, Cam...
18 CitationsSource
#1Takeshi Fukuda (SBU: Stony Brook University)H-Index: 4
#2Mingqian Huang (SBU: Stony Brook University)H-Index: 6
Last. Chuan Huang (SBU: Stony Brook University)H-Index: 13
view all 5 authors...
Objective To evaluate the correlation between bone marrow cellularity (BMC) and metabolic activity in healthy subjects and to see whether yellow marrow is indeed metabolically quiescent. Because metabolic activity can be assumed to reflect vascularity, we assessed the relationship between regional metabolic activity and geographic frequency of metastases as noted in the literature.
6 CitationsSource
#1Courtney Tate (Royal Brisbane and Women's Hospital)H-Index: 2
#1Courtney Tate (Royal Brisbane and Women's Hospital)H-Index: 1
Last. Kenneth A. Miles (Princess Alexandra Hospital)H-Index: 56
view all 3 authors...
Objective:This prospective observational study of positron emission tomography (PET)-MRI findings in 16 consecutive newly diagnosed patients with a plasma cell dyscrasia describes and compares MRI-...
2 CitationsSource
#1Carole Durot (Reims University)H-Index: 5
#2Sébastien MuléH-Index: 14
Last. Christine Hoeffel (URCA: University of Reims Champagne-Ardenne)H-Index: 27
view all 6 authors...
Purpose To determine whether texture analysis features on pretreatment contrast-enhanced computed tomography (CT) images can predict overall survival (OS) and progression-free survival (PFS) in patients with metastatic malignant melanoma (MM) treated with an anti-PD-1 monoclonal antibody, pembrolizumab.
14 CitationsSource
#1Burak KocakH-Index: 13
#2Emine Sebnem Durmaz (Istanbul University)H-Index: 8
Last. Melis Baykara UlusanH-Index: 2
view all 4 authors...
OBJECTIVE. The purpose of this study is to evaluate the potential value of machine learning (ML)–based high-dimensional quantitative CT texture analysis in predicting the mutation status of the gen...
36 CitationsSource
Cited By0
Newest