Chemoselective bioconjugation based on modular click chemistry with 4-halocoumarins and aryl sulfonates
Abstract
We report chemoselective and modular peptide bioconjugation using stoichiometric amounts of 4-halocoumarin and arylsulfonate agents that undergo metal-free C(sp2)-heteroatom bond formation at micromolar concentrations. The underlying ipso-substitution click chemistry is irreversible and generates stable and inherently fluorescent bioconjugates, and the broad selection of coumarin tags offers high labeling flexibility and versatility. Different...
Paper Details
Title
Chemoselective bioconjugation based on modular click chemistry with 4-halocoumarins and aryl sulfonates
Published Date
Jan 1, 2021
Journal
Volume
11
Issue
31
Pages
18960 - 18965
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