Sex hormone–binding globulin: biomarker and hepatokine?

Pomme I. H. G. Simons; Olivier Valkenburg; Coen D.A. Stehouwer; Martijn C. G. J. Brouwers

doi:https://doi.org/10.1016/j.tem.2021.05.002

doi.org/10.1016/j.tem.2021.05.002

Sex hormone–binding globulin: biomarker and hepatokine?

Pomme I. H. G. Simons

5

,

Olivier Valkenburg

2

,

..., Martijn C. G. J. Brouwers

22

Volume: 32, Issue: 8, Pages: 544 - 553

Published: Aug 1, 2021

Abstract

Over the past decade, there have been important breakthroughs in our understanding of the regulation and function of sex hormone-binding globulin (SHBG). A recent genome-wide association and Mendelian randomization study has provided new insights at the population level. Thorough study of genetic variants affecting serum SHBG has identified de novo lipogenesis as one of the mechanistic links between the metabolic syndrome and reduced serum SHBG...