Targeting ferroptosis in pancreatic cancer: a double-edged sword
Abstract
Pancreatic ductal adenocarcinoma (PDAC) remains an aggressive malignancy with a 5-year survival rate below 10%. Its unique genetic makeup and tumor microenvironment produce a lack of response to current treatments, including chemotherapy, radiotherapy, and immunotherapy. Recent preclinical studies have revealed that ferroptosis, an iron-dependent form of nonapoptotic cell death driven by unrestricted lipid peroxidation, may be an attractive...
Paper Details
Title
Targeting ferroptosis in pancreatic cancer: a double-edged sword
Published Date
Oct 1, 2021
Journal
Volume
7
Issue
10
Pages
891 - 901
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