Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network

Volume: 12, Issue: 11, Pages: 1083 - 1099
Published: May 25, 2021
Abstract
Background: Alzheimer’s disease is a type of dementia denoted by progressive neuronal death due to the accumulation of proteinaceous aggregates of Tau. Post-translational modifications like hyperphosphorylation, truncation, glycation, etc. play a pivotal role in Tau pathogenesis. Glycation of Tau aids in paired helical filament formation and abates its microtubule-binding function. The chemical modulators of Tau PTMs, such as kinase inhibitors...
Paper Details
Title
Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network
Published Date
May 25, 2021
Journal
Volume
12
Issue
11
Pages
1083 - 1099
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