Modulating T Follicular Cells In Vivo Enhances Antigen-Specific Humoral Immunity.
Abstract
Generation of high-affinity IgG is essential for defense against infections and cancer, which is the intended consequence of many vaccines, but can cause autoimmune and inflammatory diseases when inappropriately directed against self. The interplay of T follicular helper (TFH) cells and T follicular regulatory (TFR) cells is critical for the production of high-affinity IgG of a specific subclass. In this study, we sought to improve Ag-specific...
Paper Details
Title
Modulating T Follicular Cells In Vivo Enhances Antigen-Specific Humoral Immunity.
Published Date
May 19, 2021
Journal
Volume
206
Issue
11
Pages
2583 - 2595
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