In Regard to Tibbs et al.

Published on Jun 1, 2021in International Journal of Radiation Oncology Biology Physics7.038
· DOI :10.1016/J.IJROBP.2020.12.059
Adomas Bunevicius23
Estimated H-index: 23
(UVA: University of Virginia),
Michael W. Parsons17
Estimated H-index: 17
(Harvard University),
Jason P. Sheehan77
Estimated H-index: 77
(UVA: University of Virginia)
#1Adomas BuneviciusH-Index: 23
#2Julie J. Miller (Harvard University)H-Index: 17
Last. Michael W. Parsons (Harvard University)H-Index: 17
view all 3 authors...
PURPOSE OF REVIEW Isocitrate dehydrogenase (IDH) mutation status has important prognostic implications in glioma patients, with IDH wild-type (IDH-WT) gliomas being associated with worse prognosis and shorter survival when compared with IDH mutant (IDH-mut) gliomas. Optimization of quality of life is a priority in the management of glioma patients. The goal of this systematic review was to identify studies that explored the association of IDH mutation status with patient-reported outcomes (PROs)...
#1Michelle D. Tibbs (UCSD: University of California, San Diego)H-Index: 5
#2Minh-Phuong Huynh-Le (UCSD: University of California, San Diego)H-Index: 12
Last. Jona A. Hattangadi-Gluth (UCSD: University of California, San Diego)H-Index: 23
view all 11 authors...
ABSTRACT Background Primary brain tumor patients are vulnerable to depression and anxiety symptoms, which may affect their neurocognitive functioning. We performed a prospective longitudinal analysis to examine the association between depression and anxiety symptoms and domain-specific neurocognitive functioning in primary brain tumor patients receiving radiation therapy [RT]. Methods On a prospective trial, 54 primary brain tumor patients receiving RT underwent comprehensive neurocognitive eval...
#1Emma van Kessel (UU: Utrecht University)H-Index: 3
#2Tom J. Snijders (UU: Utrecht University)H-Index: 16
Last. Pierre Robe (UU: Utrecht University)H-Index: 28
view all 8 authors...
Purpose Deficits in neurocognitive functioning (NCF) frequently occur in glioma patients. Both treatment and the tumor itself contribute to these deficits. In order to minimize the harmful effects of surgery, an increasing number of patients undergo awake craniotomy. To investigate whether we can indeed preserve cognitive functioning after state-of-the art awake surgery and to identify factors determining postoperative NCF, we performed a retrospective cohort study.
#1Ori BarzilaiH-Index: 35
#2Shlomit Ben MosheH-Index: 2
Last. Zvi RamH-Index: 60
view all 6 authors...
OBJECTIVECognition is a key component in health-related quality of life (HRQoL) and is currently incorporated as a major parameter of outcome assessment in patients treated for brain tumors. The effect of surgery on cognition and HRQoL remains debatable. The authors investigated the impact of resection of low-grade gliomas (LGGs) on cognition and the correlation with various histopathological markers.METHODSA retrospective analysis of patients with LGG who underwent craniotomy for tumor resectio...
#1Michele Ceccarelli (University of Sannio)H-Index: 31
#2Floris P. Barthel (VU: VU University Amsterdam)H-Index: 12
Last. Stefano Maria PagnottaH-Index: 8
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Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic glioma driving alterations and suboptimal disease classification. We defined the complete set of genes associated with 1,122 diffuse grade II-III-IV gliomas from The Cancer Genome Atlas and used molecular profiles to improve disease classification, identify molecular correlations, and provide insights into the progression from low- to high-grade disease. Whole-genome sequencing data analysis determined th...
BACKGROUND: Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II and III) have highly variable clinical behavior that is not adequately predicted on the basis of histologic class. Some are indolent; others quickly progress to glioblastoma. The uncertainty is compounded by interobserver variability in histologic diagnosis. Mutations in IDH, TP53, and ATRX and codeletion of chromosome arms 1p and 19q (1p/19q codeletio...
#1Caroline HouillierH-Index: 26
#2X WangH-Index: 10
Last. J.-Y. DelattreH-Index: 16
view all 13 authors...
Objectives: Recent studies have shown that IDH1 and IDH2 mutations occur frequently in gliomas, including low-grade gliomas. However, their impact on the prognosis and chemosensitivity of low-grade gliomas remains unclear. Methods: Search for IDH1 and IDH2 mutations, loss of heterozygosity on chromosomes 1p and 19q, MGMT promoter methylation, and p53 expression was performed in a series of 271 low-grade gliomas and correlated with overall survival. A subgroup of 84 patients treated up-front with...
#1Hai Yan (Duke University)H-Index: 63
#2D. Williams ParsonsH-Index: 32
Last. Darell D. Bigner (Duke University)H-Index: 147
view all 18 authors...
Background A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase 1 gene (IDH1) in a fraction of such tumors, most frequently in tumors that were known to have evolved from lower-grade gliomas (secondary glioblastomas). Methods We determined the sequence of the IDH1 gene and the related IDH2 gene in 445 central nervous system (CNS) tumors and 494 non-CNS tumors. The enzymatic activity o...
#1D. Williams Parsons (BCM: Baylor College of Medicine)H-Index: 32
#2Siân Jones (HHMI: Howard Hughes Medical Institute)H-Index: 36
Last. Kenneth W. Kinzler (HHMI: Howard Hughes Medical Institute)H-Index: 224
view all 33 authors...
Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes, determined the presence of amplifications and deletions using high-density oligonucleotide arrays, and performed gene expression analyses using next-generation sequencing technologies in 22 human tumor samples. This comprehensive analysis led to the discovery of a variety of genes that were not known to be altered in GBMs. Most n...
Cited By1
#1Mia A Salans (UCSD: University of California, San Diego)H-Index: 3
#2Michelle D. Tibbs (UCSD: University of California, San Diego)H-Index: 5
Last. Jona A. Hattangadi-Gluth (UCSD: University of California, San Diego)H-Index: 23
view all 4 authors...
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