Uncertainty in denoising of MRSI using low‐rank methods

Purpose Low‐rank denoising of MRSI data results in an apparent increase in spectral SNR. However, it is not clear if this translates to a lower uncertainty in metabolite concentrations after spectroscopic fitting. Estimation of the true uncertainty after denoising is desirable for downstream analysis in spectroscopy. In this work, the uncertainty reduction from low‐rank denoising methods based on spatiotemporal separability and linear...