Association Between Diarrhea Duration and Severity and Probiotic Efficacy in Children With Acute Gastroenteritis

INTRODUCTION: It is unclear whether the alleged efficacy of probiotics in childhood acute gastroenteritis depends on the duration and severity of symptoms before treatment. METHODS: Preplanned secondary analysis of 2 randomized placebo-controlled trials in children 3–48 months of age was conducted in 16 emergency departments in North America evaluating the efficacy of 2 probiotic products ( Lactobacillus rhamnosus GG and a combination probiotic:...