Emerging role of carbonic anhydrase inhibitors
Abstract
Inhibition of carbonic anhydrase (CA, EC 4.2.1.1) was clinically exploited for decades, as most modern diuretics were obtained considering as lead molecule acetazolamide, the prototypical CA inhibitor (CAI). The discovery and characterization of multiple human CA (hCA) isoforms, 15 of which being known today, led to new applications of their inhibitors. They include widely clinically used antiglaucoma, antiepileptic and antiobesity agents,...
Paper Details
Title
Emerging role of carbonic anhydrase inhibitors
Published Date
May 1, 2021
Journal
Volume
135
Issue
10
Pages
1233 - 1249
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Notes
History