Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy

Volume: 75, Issue: 3, Pages: 647 - 658
Published: Sep 1, 2021
Abstract
COVID-19 is associated with liver injury and elevated interleukin-6 (IL-6). We hypothesized that IL-6 trans-signaling in liver sinusoidal endothelial cells (LSECs) leads to endotheliopathy (a proinflammatory and procoagulant state) and liver injury in COVID-19.Coagulopathy, endotheliopathy, and alanine aminotransferase (ALT) were retrospectively analyzed in a subset (n = 68), followed by a larger cohort (n = 3,780) of patients with COVID-19....
Paper Details
Title
Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy
Published Date
Sep 1, 2021
Volume
75
Issue
3
Pages
647 - 658
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