Semi-enzymatic synthesis of pseudouridine

Volume: 44, Pages: 128105 - 128105
Published: Jul 1, 2021
Abstract
Modifications of RNA molecules have a significant effect on their structure and function. One of the most common modifications is the isomerization from uridine to pseudouridine. Despite its prevalence in natural RNA sequences, organic synthesis of pseudouridine has been challenging because of the stereochemistry requirement and the sensitivity of reaction steps to moisture. Herein, a semi-enzymatic synthetic route is developed for the synthesis...
Paper Details
Title
Semi-enzymatic synthesis of pseudouridine
Published Date
Jul 1, 2021
Journal
Volume
44
Pages
128105 - 128105
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