Long-read whole-genome methylation patterning using enzymatic base conversion and nanopore sequencing
Abstract
Long-read whole-genome sequencing analysis of DNA methylation would provide useful information on the chromosomal context of gene expression regulation. Here we describe the development of a method that improves the read length generated by using the bisulfite-sequencing-based approach. In this method, we combined recently developed enzymatic base conversion, where an unmethylated cytosine (C) should be converted to thymine (T), with nanopore...
Paper Details
Title
Long-read whole-genome methylation patterning using enzymatic base conversion and nanopore sequencing
Published Date
May 21, 2021
Journal
Volume
49
Issue
14
Pages
e81 - e81
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