The oncological relevance of fragile sites in cancer
Abstract
Recent developments in sequencing the cancer genome have provided the first in-depth mapping of structural variants (SV) across 38 tumour types. Sixteen signatures of structural variants have been proposed which broadly characterise the variation seen across cancer types. One signature shows increased duplications and deletions at fragile sites, with little association with the typical DNA repair defects. We discuss how, for many of these...
Paper Details
Title
The oncological relevance of fragile sites in cancer
Published Date
May 12, 2021
Journal
Volume
4
Issue
1
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