Synthesis and bioactivity studies of covalent inhibitors derived from (-)-Chaetominine
Abstract
• More than 34 new analogues of Chaetominine have been synthesized. • These new analogues feature versatile electrophilic warheads. • Some analogues show improved antitumor activities in cancer cell lines compared to Chaetominine. We reported herein the synthesis and bioactivity studies of compounds derived from the natural product (-)-Chaetominine ( 6 ). The key feature of these compounds is the incorporation of electrophilic groups that are...
Paper Details
Title
Synthesis and bioactivity studies of covalent inhibitors derived from (-)-Chaetominine
Published Date
Oct 1, 2021
Volume
1241
Pages
130694 - 130694
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