The role of ligand-binding assay and LC–MS in the bioanalysis of complex protein and oligonucleotide therapeutics

Volume: 13, Issue: 11, Pages: 931 - 954
Published: Jun 1, 2021
Abstract
Ligand-binding assay (LBA) and LC-MS have been the preferred bioanalytical techniques for the quantitation and biotransformation assessment of various therapeutic modalities. This review provides an overview of the applications of LBA, LC-MS/MS and LC-HRMS for the bioanalysis of complex protein therapeutics including antibody-drug conjugates, fusion proteins and PEGylated proteins as well as oligonucleotide therapeutics. The strengths and...
Paper Details
Title
The role of ligand-binding assay and LC–MS in the bioanalysis of complex protein and oligonucleotide therapeutics
Published Date
Jun 1, 2021
Volume
13
Issue
11
Pages
931 - 954
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