Modeling Joint Pain on a Chip: integrating sensory neurons in the microJoint to model osteoarthritis
Abstract
The development of safe and effective methods for the treatment of osteoarthritis(OA)-associated pain is a critical need. Recently, our team successfully modeled OA-like pathology in an in vitro multi-component joint-on-a-chip (microJoint), which integrates engineered osteochondral complex, synovium, adipose tissue and given their crucial role in joint pain, macrophages. In the present project, we introduce the sensory neurons into the...
Paper Details
Title
Modeling Joint Pain on a Chip: integrating sensory neurons in the microJoint to model osteoarthritis
Published Date
May 1, 2021
Journal
Volume
22
Issue
5
Pages
583
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