The use of human acellular dermal matrices in advanced wound healing and surgical procedures: State of the art.

Published on May 15, 2021in Dermatologic Therapy2.327
· DOI :10.1111/DTH.14987
Linda Tognetti11
Estimated H-index: 11
(UNISI: University of Siena),
Elisa Pianigiani14
Estimated H-index: 14
(UNISI: University of Siena)
+ 6 AuthorsPietro Rubegni32
Estimated H-index: 32
(UNISI: University of Siena)
Wound closure after post-traumatic injuries and/or localized at peculiar body sites (head-and-neck, oral cavity, legs) are particularly challenging and can often be delayed due to local and systemic factors. In case of deep wounds and/or hard-to-heal wounds, grafting of dermal acellular matrices (ADM) is often needed. Though a great variety of synthetic and semisynthetic dermal and skin equivalents are available, viable human dermis, is still considered the most physiological alternative to replace the loss of autologous dermis, by acting as a physiological scaffold that add structural support to soft tissues. To date, human ADMs (hADMs) have been employed in the reconstruction of skin defects affecting almost all body sites, ranging from visceral sites to the skin and subcutaneous tissues. This review aims to investigate the use of hADM at different body sites and their peculiar advantages. A literature search was using the search terms "acellular dermal matrices", "dermal regeneration", "advances wound healing", "human acellular dermal matrices surgery". A total of 50 out of 150 papers was included. Based on the current body if evidence, hADMs appear to bring several advantages, such as: protection of deep structures (e.g. tendons, bones, cartilage and nerves); stimulation of a functional new dermis (rather than a scar); reduction of wound closure time; control of pain and exudate. Finally, hADMs may represent the best treatment option for hard-to-heal wound not only in terms of efficacy and patient satisfaction bout also in terms of sanitary costs, especially across Europe, where hADMs cannot be commercialized as medical devices. This article is protected by copyright. All rights reserved.
📖 Papers frequently viewed together
13 Authors (Linda Tognetti, ..., Pietro Rubegni)
2 Citations
#1Jeremiah P. Tao (UCI: University of California, Irvine)H-Index: 10
#2Vinay K. Aakalu (UIC: University of Illinois at Chicago)H-Index: 14
Last. Michael T. Yen (BCM: Baylor College of Medicine)H-Index: 16
view all 7 authors...
Purpose To review the literature on the efficacy and safety of bioengineered acellular dermal matrix (BADM) grafts for lower eyelid retraction repair. Methods A literature search was conducted in the PubMed database initially in January 2018 and updated in July 2019 to identify all studies in the English language literature on the use of BADM grafts in eyelid reconstruction. The searches yielded 193 citations, and 15 of the 34 articles selected for full review met all inclusion criteria for this...
2 CitationsSource
The closure of wounds associated with soft tissue defects is surgically challenging, frequently requiring extensive plastic surgery and free flaps. The combination of ADM and STSG is an innovative ...
1 CitationsSource
#1Linda TognettiH-Index: 11
#2Ernesto DePianoH-Index: 1
Last. Pietro Rubegni (UNISI: University of Siena)H-Index: 32
view all 13 authors...
Although the main field of application of homologous skin grafts from donor skin is extensive burns, they can be successfully used in a variety of critical and/or hard-to-heal wounds. Wound closure after post-traumatic injuries and/or localized at peculiar body sites (head and neck, oral cavity, lower legs) is particularly challenging and can often be delayed due to local and systemic factors (e.g., bacterial burden, infections, diabetic neuropathy, and pressure). In these cases, integrated medi...
#1Linda Tognetti (UNISI: University of Siena)H-Index: 11
#2Francesca Ierardi (UNISI: University of Siena)H-Index: 8
Last. Elisa Pianigiani (UNISI: University of Siena)H-Index: 14
view all 8 authors...
Skin banks are tissue establishments dedicated to the procurement, processing, and distribution of human-derived skin bioproducts for clinical purposes. A skin bank must observe national/international guidelines and perform standardized procedures to ensure tissue traceability and biological safety in all processing stages and to avoid potential biological contamination. In order to minimize the risk of transmission of pathogenic agents, rigorous donor screening, extensive microbiological and se...
#1Hailei Guo (First Affiliated Hospital of Wenzhou Medical University)H-Index: 2
#2Ling XwH-Index: 1
Last. Lu CjH-Index: 1
view all 6 authors...
Objective: To explore the clinical effects of split-thickness scalp and allogenic acellular dermal matrix (ADM) in repairing deep wounds of hands in patients with extremely extensive burns. Methods: Six patients with extremely extensive burns complicated by deep burn in hands were admitted to our department from December 2014 to December 2017, including 4 males and 2 females, aged 21 to 58 years. Their total burn areas were from 85% to 95% total body surface area (TBSA), and the sum of deep-part...
#1Rakesh John (Dal: Dalhousie University)H-Index: 2
#2Catherine Coady (Dal: Dalhousie University)H-Index: 6
Last. Ivan Wong (Dal: Dalhousie University)H-Index: 16
view all 3 authors...
Abstract Latissimus dorsi tendon transfer is a nonanatomic tendon transfer that is often considered a salvage procedure for failed repairs of massive rotator cuff tears. A rupture of the transferred latissimus tendon is an uncommon complication and there is limited literature on its management, especially in the young, active population without cuff arthropathy. In this article, we present a technique of managing a failed latissimus dorsi tendon transfer for a massive rotator cuff tear with an a...
2 CitationsSource
#1Ran Stein (TAU: Tel Aviv University)H-Index: 3
#2Sara Núñez Márquez (McMaster University)H-Index: 1
Last. Yasser Khan (McMaster University)H-Index: 4
view all 4 authors...
2 CitationsSource
#1J. Cheon (KU: Korea University)H-Index: 8
#2Eul Sik Yoon (KU: Korea University)H-Index: 19
Last. Byung Il Lee (KU: Korea University)H-Index: 11
view all 5 authors...
BACKGROUND: In implant-based breast reconstruction, acellular dermal matrix (ADM) is essential for supporting the inferolateral pole. Recent studies have compared non-sterilized freeze-dried ADM and sterilized pre-hydrated ADM, but have not assessed whether differences were attributable to factors related to sterile processing or packaging. This study was conducted to compare the clinical outcomes of breast reconstruction using two types of sterile-processed ADMs. METHODS: Through a retrospectiv...
2 CitationsSource
#1Elena Bondioli (AUSL: Academy for Urban School Leadership)H-Index: 8
#2Valeria Purpura (AUSL: Academy for Urban School Leadership)H-Index: 5
Last. Davide Melandri (AUSL: Academy for Urban School Leadership)H-Index: 8
view all 10 authors...
Full-thickness skin wounds occur in many different clinical cases and the use of biological acellular dermal matrices (ADMs) to reconstruct the damaged area is increasing in the field of plastic and reconstructive surgery. In particular, the ability of ADMs to maintain the structural properties of extracellular matrix as well as to provide a suitable environment for cell growth makes their use suitable for the improvement of wound healing and the reduction of side effects deriving from contractu...
1 CitationsSource
#1Matteo Torresetti (Marche Polytechnic University)H-Index: 9
#2Alessandro Scalise (Marche Polytechnic University)H-Index: 13
Last. Giovanni Di Benedetto (Marche Polytechnic University)H-Index: 14
view all 3 authors...
Abstract Introduction nasal reconstruction after rhinophyma surgery could be challenging. In the last decade, some authors proposed the use of dermal substitutes, but only few case reports have been described throughout the Literature. Presentation of case we described a new case of severe and disfiguring rhinophyma treated by total excision and a two-step reconstruction by using acellular dermal matrix and subsequent full-thickness skin graft. Despite an overall improvement of the nasal shape a...
1 CitationsSource
Cited By1
Surgical mesh reinforcement of the human abdominal wall has been found to reduce the chance of recurrence in hernia repairs. While traditionally polymer meshes have been used in hernia repair, alternative mesh options have been engineered to prevent the inflammatory foreign body response invoked by polymers. A reinforced tissue matrix (RTM) mesh has been developed by embedding a polymer within a decellularized extracellular matrix. This combination has been attributed to the recruitment of host ...