Dynamic precise dual-drug-backboned nano-prodrugs for selective chemotherapy
Abstract
To achieve an ideal drug delivery platform with precise composition and high tumor selectivity, the PEGylated dual-drug backboned prodrug was synthesized via the copolymerization between diamine monomer of ortho ester and cisplatin- demethylcantharidin conjugate (Pt(IV)-1), and then terminated by mPEG550-active ester. The amphipathic prodrug could self-assemble into nano-prodrugs, which endowed the precise structure and high drug loading....
Paper Details
Title
Dynamic precise dual-drug-backboned nano-prodrugs for selective chemotherapy
Published Date
Jul 1, 2021
Journal
Volume
129
Pages
209 - 219
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