Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth
Abstract
During mammalian brain development, neural progenitor cells proliferate extensively but can ensure the production of correct numbers of various types of mature cells by balancing symmetric proliferative versus asymmetric differentiative cell divisions. This process of cell fate determination may be harnessed for developing cancer therapy. Here, we test this idea by targeting KIF20A, a mitotic kinesin crucial for the control of cell division...
Paper Details
Title
Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth
Published Date
May 11, 2021
Journal
Volume
4
Issue
1
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