A systematic review and network meta-analysis of the safety of early interventional treatments in rheumatoid arthritis

To evaluate the safety of treatment strategies in patients with early RA.Systematic searches of MEDLINE, EMBASE and PubMed were conducted up to September 2020. Double-blind randomized controlled trials (RCTs) of licensed treatments conducted on completely naïve or MTX-naïve RA patients were included. Long-term extension studies, post-hoc and pooled analyses and RCTs with no comparator arm were excluded. Serious adverse events, serious infections...