Tumor- and osteoclast-derived NRP2 in prostate cancer bone metastases
Abstract
Understanding the role of neuropilin 2 (NRP2) in prostate cancer cells as well as in the bone microenvironment is pivotal in the development of an effective targeted therapy for the treatment of prostate cancer bone metastasis. We observed a significant upregulation of NRP2 in prostate cancer cells metastasized to bone. Here, we report that targeting NRP2 in cancer cells can enhance taxane-based chemotherapy with a better therapeutic outcome in...
Paper Details
Title
Tumor- and osteoclast-derived NRP2 in prostate cancer bone metastases
Published Date
May 14, 2021
Journal
Volume
9
Issue
1
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