MicroRNA-142 Critically Regulates Group 2 Innate Lymphoid Cell Homeostasis and Function

Volume: 206, Issue: 11, Pages: 2725 - 2739
Published: Jun 1, 2021
Abstract
Innate lymphoid cells are central to the regulation of immunity at mucosal barrier sites, with group 2 innate lymphoid cells (ILC2s) being particularly important in type 2 immunity. In this study, we demonstrate that microRNA(miR)-142 plays a critical, cell-intrinsic role in the homeostasis and function of ILC2s. Mice deficient for miR-142 expression demonstrate an ILC2 progenitor-biased development in the bone marrow, and along with peripheral...
Paper Details
Title
MicroRNA-142 Critically Regulates Group 2 Innate Lymphoid Cell Homeostasis and Function
Published Date
Jun 1, 2021
Volume
206
Issue
11
Pages
2725 - 2739
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