Promising Technological and Industrial Applications of Deep Eutectic Systems

Published on May 12, 2021in Materials3.057
· DOI :10.3390/MA14102494
Alberto Mannu11
Estimated H-index: 11
Marco Blangetti14
Estimated H-index: 14
+ 1 AuthorsCristina Prandi26
Estimated H-index: 26
Deep Eutectic Systems (DESs) are obtained by combining Hydrogen Bond Acceptors (HBAs) and Hydrogen Bond Donors (HBDs) in specific molar ratios. Since their first appearance in the literature in 2003, they have shown a wide range of applications, ranging from the selective extraction of biomass or metals to medicine, as well as from pollution control systems to catalytic active solvents and co-solvents. The very peculiar physical properties of DESs, such as the elevated density and viscosity, reduced conductivity, improved solvent ability and a peculiar optical behavior, can be exploited for engineering modular systems which cannot be obtained with other non-eutectic mixtures. In the present review, selected DESs research fields, as their use in materials synthesis, as solvents for volatile organic compounds, as ingredients in pharmaceutical formulations and as active solvents and cosolvents in organic synthesis, are reported and discussed in terms of application and future perspectives.
Figures & Tables
#1Xin Tong (ZJNU: Zhejiang Chinese Medical University)H-Index: 2
#2Jiehong Yang (ZJNU: Zhejiang Chinese Medical University)H-Index: 11
Last. Chang Li (ZJNU: Zhejiang Chinese Medical University)H-Index: 12
view all 8 authors...
Abstract Natural deep eutectic solvents (NaDESs) are promising green alternatives to conventional solvents widely applied in the extraction of natural products due to their physical and chemical superiorities. In present study, 22 NaDESs consisted from food grade ingredients were screened in ultrasonic assisted extraction (UAE) of bioactive compounds from safflower. The oral bioavailabilities of hydroxysafflor yellow A (HSYA) and anhydrosafflor yellow B (ASYB) in the extracts were then investiga...
5 CitationsSource
Abstract Three natural deep eutectic solvents (NADES; choline chloride (CC): lactic acid (LA), CC: oxalic acid (OA), CC: urea (U)) in the ratio 1:2 were tested as a pretreatment of apple pomace prior to hot water extraction of pectin. The pretreatment duration and temperature (for 0.5-2h, at 40-80 °C) was adjusted to limit cell wall polysaccharides losses and degradation. Extraction yields and sugar composition were used to evaluate the impact of the pretreatment on pectin extraction and the mol...
10 CitationsSource
#1Alberto Mannu (UNITO: University of Turin)H-Index: 11
#2Francesca Cardano (UNITO: University of Turin)H-Index: 2
Last. Cristina Prandi (UNITO: University of Turin)H-Index: 26
view all 5 authors...
Abstract The structural features derived by the UV-VIS spectroscopical analysis of five ternary eutectic systems containing choline chloride as Hydrogen Bond Acceptor (HBA), and ethylene glycol and a second Hydrogen Bond Donor (HBD, water, glycerol, methanol, ethanol, and 2-propanol), have been determined and described in terms of band gap and Urbach energies (BGE and UE). In particular, the relationship between the molar composition of the ternary eutectic systems and the BG and U energies was ...
2 CitationsSource
#1Rita Craveiro (NOVA: Universidade Nova de Lisboa)H-Index: 9
#2Vânia I. B. Castro (University of Minho)H-Index: 4
Last. Alexandre Paiva (NOVA: Universidade Nova de Lisboa)H-Index: 25
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Abstract Natural deep eutectic systems (NADES), which have applications as solvents for both engineering and life sciences, are mainly composed of sugars, aminoacids or organic acids. In this work NADES composed by glucose, urea and proline (G:U:P in a molar ratio of 1:1:1) and proline and glucose (P:G 5:3) were prepared and added in different mass fractions to water. By differential scanning calorimetry it was verified as the crystallization tendency of water is modified even for low fraction o...
1 CitationsSource
#1Helene Liepelt Nystedt (University of Oslo)H-Index: 1
#2Krister Gjestvang Grønlien (University of Oslo)H-Index: 2
Last. Hanne Hjorth Tønnesen (University of Oslo)H-Index: 31
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Abstract Natural deep eutectic solvents (NADES) are a third type of liquids, apart from water and lipids. NADES show promise as drug carriers in dermal formulations or formulations for local administration in the oral cavity due to their low toxicity, tunability and biodegradability as well as their solubilizing and stabilizing properties. However, a thorough investigation of their effects in a biological system is needed. The present study aimed to investigate the physicochemical properties of ...
4 CitationsSource
#1Zhifang Cui (SDUST: Shandong University of Science and Technology)
#2Alexandra Victoria Enjome Djocki (SDUST: Shandong University of Science and Technology)H-Index: 1
Last. Chunlu Li (SDUST: Shandong University of Science and Technology)H-Index: 3
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Abstract To reduce the environmental pollution caused by organic solvents and improve the extraction efficiency, a range of natural deep eutectic solvents (NADESs) was explored for the extraction of green tea polyphenols (TPs). The use of the NADESs, especially ChCl/EG (Choline chloride/Ethylene glycol, molar ratio 1:2), can increase extraction efficiency when comparing with the traditional solvents. Then response surface methodology (RSM) was used for the optimization of TPs extraction with ChC...
4 CitationsSource
#1Marzia CavalloH-Index: 1
#2Davide ArnodoH-Index: 2
Last. Salvatore BaldinoH-Index: 14
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Abstract The employment of easily affordable ruthenium(II)-complexes as pre-catalysts in the transfer hydrogenation of carbonyl compounds in deep eutectic media is described for the first time. The eutectic mixture tetrabutylammonium bromide/formic acid = 1/1 (TBABr/HCOOH = 1/1) acts both as reaction medium and hydrogen source. The addition of a base is required for the process to occur. An extensive optimization of the reaction conditions has been carried out, in terms of catalyst loading, type...
3 CitationsSource
#1Manuela Panić (University of Zagreb)H-Index: 6
#2Mia Radović (University of Zagreb)H-Index: 1
Last. Ivana Radojčić Redovniković (University of Zagreb)H-Index: 21
view all 6 authors...
Abstract Over the past decade, natural deep eutectic solvents (NADES) have become promising green solvent from both environmental and technological perspectives. The number of structural combinations encompassed by NADES is tremendous; thus, NADES with unique physicochemical properties can be designed for a particular purpose, such as for efficient biocatalytic processes. The aim of this work was to prepare several NADES based on renewable sources (biomass energy) and to apply these solvents in ...
2 CitationsSource
#1Vikash Chandra Roy (Pukyong National University)H-Index: 2
#2Truc Cong Ho (Pukyong National University)H-Index: 4
Last. Byung-Soo Chun (Pukyong National University)H-Index: 26
view all 8 authors...
Abstract The present work focuses on astaxanthin (ASX) extraction from shrimp wastes using ultrasound-assisted extraction (UAE) natural deep eutectic solvents (NaDESs) and the utilization of ASX-rich DES extract (ASX-DES extract) for preparing biodegradable active packaging. The effect of hydrogen bond donor (HBD)/acceptor (HBA) molar ratio, ultrasound amplitude, and extraction time for the ASX extraction was observed, and influential parameters were optimized using three-level-factor Box-Behnke...
5 CitationsSource
#1Giorgio Grillo (UNITO: University of Turin)H-Index: 9
#2Emanuela Calcio Gaudino (UNITO: University of Turin)H-Index: 17
Last. Giancarlo Cravotto (UNITO: University of Turin)H-Index: 64
view all 8 authors...
Aiming to fulfil the sustainability criteria of future biorefineries, a novel biomass pretreatment combining natural deep eutectic solvents (NaDESs) and microwave (MW) technology was developed. Results showed that NaDESs have a high potential as green solvents for lignin fractionation/recovery and sugar release in the following enzymatic hydrolysis. A new class of lignin derived NaDESs (LigDESs) was also investigated, showing promising effects in wheat straw delignification. MW irradiation enabl...
3 CitationsSource
Cited By1
#1Alberto Mannu (UNITO: University of Turin)H-Index: 11
#2Francesca Cardano (UNITO: University of Turin)H-Index: 2
Last. Andrea Fin (UNITO: University of Turin)H-Index: 13
view all 4 authors...
Three ternary mixtures composed by choline chloride (ChCl), ethylene glycol (EG), and a second hydrogen bond donor (HBD) as ethanol (A), 2-propanol (B), and glycerol (C) were studied in terms of composition related to the band gap energy (BGE). A Design of Experiments (DoE) approach, and in particular a Simple Lattice three-components design, was employed for determining the variation of the BGE upon the composition of each system. UV-VIS analysis and subsequent Tauc plot methodology provided th...