Bioinspired adhesive and tumor microenvironment responsive nanoMOFs assembled 3D-printed scaffold for anti-tumor therapy and bone regeneration

Tumor-induced bone loss is the main reason causing bone tumor therapy failure. Rational design of implants with both anti-tumor and bone tissue regeneration functions is urgently needed. This study presents a 3D-printed implant that simultaneously releases anti-cancer drugs and growth factors for anti-tumor therapy and osteogenesis. Such an implant was realized by alternatively assembling polydopamine (PDA)-hybridized nanosized zeolitic...