Role of RNA N6-Methyladenosine Modification in Male Infertility and Genital System Tumors

Published on May 19, 2021in Frontiers in Cell and Developmental Biology5.201
· DOI :10.3389/FCELL.2021.676364
Shuai Liu , Yongfeng Lao + 5 AuthorsZhi-Long Dong3
Estimated H-index: 3
#1Kai Zhu (Southern Medical University)H-Index: 1
#2Ying Li (Changzhi Medical College)H-Index: 1
Last. Yikai Xu (Southern Medical University)H-Index: 1
view all 3 authors...
Abstract Aims N6-Methyladenosine (m6A) is the most frequent posttranscriptional modification and plays important roles in tumorigenesis and metastasis. The roles of fat mass and obesity-associated (FTO) in metabolic diseases have been widely explored. However, the molecular mechanisms and physiological functions of FTO in prostate cancer remain largely unknown. This study aimed to explore the exact functions of FTO in the progression of prostate cancer metastasis. Main methods Dot blot and m6A R...
#1Yabing Chen (NU: Nanjing University)H-Index: 10
#2Jing Wang (NU: Nanjing University)H-Index: 1
Last. Xiaodong Han (NU: Nanjing University)H-Index: 62
view all 8 authors...
AbstractMacroautophagy/autophagy is indispensable for testosterone synthesis in Leydig cells (LCs), and here we report a negative association between m6A modification and autophagy in LCs during te...
14 CitationsSource
#1Qunying Wu (Guangxi Medical University)H-Index: 3
#2Xing XieH-Index: 2
Last. Yanling HuH-Index: 17
view all 7 authors...
Prostate cancer (PCa) is one of the most common epithelial malignant tumors and the fifth leading cause of cancer death in men. An increasing number of studies have demonstrated that N6-methyladenosine (m6A) plays a crucial role in tumorigenesis and tumor development. However, little is known about the role and levels of common m6A regulators and m6A levels in PCa. In this study, we analyzed the characteristic expression of m6A regulators in PCa and castration-resistant prostate cancer (CRPC). U...
#1Lifang Ma (SJTU: Shanghai Jiao Tong University)H-Index: 16
#1Lifang Ma (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last. Jiayi Wang (Tongji University)H-Index: 1
view all 16 authors...
Abstract The biological functions of N6-methyladenosine (m6A) RNA methylation are mainly dependent on the reader; however, its role in lung tumorigenesis remains unclear. Here, we have demonstrated that the m6A reader YT521-B homology domain containing 2 (YTHDC2) is frequently suppressed in lung adenocarcinoma (LUAD). Downregulation of YTHDC2 was associated with poor clinical outcome of LUAD. YTHDC2 decreased tumorigenesis in a spontaneous LUAD mouse model. Moreover, YTHDC2 exhibited antitumor a...
5 CitationsSource
#1Tian-Xin ZhaoH-Index: 2
#2Jun-Ke WangH-Index: 2
Last. Guanghui WeiH-Index: 6
view all 10 authors...
Abstract N6-methyladenosine (m6A) modification, the most prevalent form of RNA methylation, modulates gene expression post-transcriptionally. Di-(2-ethylhexyl) phthalate (DEHP) is a common environmental endocrine disrupting chemical that induces testicular injury due to the inhibition of the demethylase fat mass and obesity-associated protein (FTO) and increases the m6A modification. How FTO-mediated m6A modification in testicular Leydig cell injury induced by DEHP remains unclear. Here, the TM3...
3 CitationsSource
#1Rebecca L. Siegel (ACS: American Cancer Society)H-Index: 67
#2Kimberly D. Miller (ACS: American Cancer Society)H-Index: 28
Last. Ahmedin Jemal (ACS: American Cancer Society)H-Index: 140
view all 4 authors...
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population-based cancer occurrence. Incidence data (through 2017) were collected by the Surveillance, Epidemiology, and End Results Program; the National Program of Cancer Registries; and the North American Association of Central Cancer Registries. Mortality data (through 2018) were collected by the National Center for Health Statistics. In 2021, 1...
157 CitationsSource
#1Simeng Wen (Tianjin Medical University)H-Index: 2
#2Yulei WeiH-Index: 2
Last. Yu Zhao (Mayo Clinic)H-Index: 2
view all 6 authors...
Background N6-methyladenosine (m6A) is the most prevalent messenger RNA modification in mammalian cells. However, the disease relevant function of m6A on specific oncogenic long non-coding RNAs (ncRNAs) is not well understood. Methods We analyzed the m6A status using patients samples and bone metastatic PDXs. Through m6A high-throughput sequencing, we identified the m6A sites on NEAT1-1 in prostate bone metastatic PDXs. Mass spec assay showed interaction among NEAT1-1, CYCLINL1 and CDK19. RNA EM...
4 CitationsSource
#1Yang Li (Fudan University)H-Index: 1
#2Ji-Na Zheng (Fudan University)H-Index: 1
Last. XiaoJun Ding (Fudan University)H-Index: 2
view all 6 authors...
Background Increasing evidence has shown that N6-methyladenosine (m6A) RNA methylation regulators have important biological functions in human cancers. However, there are few studies on the value of m6A reader protein YTHDC2 in the diagnosis and tumor-infiltrating of head and neck squamous cell carcinoma (HNSCC). Therefore, it is important to understand the potential clinical value of YTHDC2 in the prognosis and immune infiltration of HNSCC. Methods In this study, gene expression profiles and th...
2 CitationsSource
#1Junjie XuH-Index: 5
#2Zhe WanH-Index: 4
Last. Xiujun CaiH-Index: 8
view all 13 authors...
Background and aims Accumulating evidence suggests that the primary and acquired resistance of hepatocellular carcinoma (HCC) to sorafenib is mediated by multiple molecular, cellular, and microenvironmental mechanisms. Understanding these mechanisms will enhance the likelihood of effective sorafenib therapy. Methods In vitro and in vivo experiments were performed and clinical samples and online databases were acquired for clinical investigation. Results In this study, we found that a circular RN...
6 CitationsSource
#1Zhaolong Zhang (Qingdao University)H-Index: 2
#2Qiuhan Wang (Qingdao University)H-Index: 1
Last. Rui Xu (Qingdao University)H-Index: 2
view all 10 authors...
YTH Domain Containing 1 (YTHDC1) is one of the m6A readers that is essential for oocyte development and tumor progression. The role of YTHDC1 in neuronal survival and ischemic stroke is unknown. Here, we found that YTHDC1 was unregulated in the early phase of ischemic stroke. Knockdown of YTHDC1 exacerbated ischemic brain injury and overexpression of YTHDC1 protected rats against brain injury. Mechanistically, YTHDC1 promoted PTEN mRNA degradation to increase Akt phosphorylation, thus facilitati...
Cited By0