Native Mitochondria-Targeting polymeric nanoparticles for mild photothermal therapy rationally potentiated with immune checkpoints blockade to inhibit tumor recurrence and metastasis

Photothermal therapy (PTT) is a promising therapeutic modality, but still faces some potential limitations, such as unfavorable thermal damage to normal tissues, limited light penetration depth, unpredictable tumor recurrence and metastasis. Additionally, mitochondria play a key role in maintaining multiple cellular functions, whereas displaying fragile thermal sensitivity. Herein, we report on the fabrication of an immunomodulator (R848)-loaded...