Long‐term pre‐clinical evaluation of an injectable chitosan nanocellulose hydrogel with encapsulated adipose‐derived stem cells in an ovine model for IVD regeneration

The potential therapeutic benefit of adipose-derived stem cells (ASCs) encapsulated in an injectable hydrogel for stimulating intervertebral disc (IVD) regeneration has been assessed by a number of translational and preclinical studies. However, previous work has been primarily limited to small animal models and short-term outcomes of only a few weeks. Long-term studies in representative large animal models are crucial for translation into...