Wound Healing Myofibroblasts Proliferate Clonally and in a Mechanoresponsive Manner

INTRODUCTION: Fibroblasts are integral in regulating tissue homeostasis. Notably, activated fibroblasts (myofibroblasts) play critical roles in wound healing including producing and depositing extracellular matrix and driving wound closure. Much research has been aimed at characterizing subpopulations of fibroblasts with specific activities in wound healing; however, information regarding the origins and heterogeneity of myofibroblasts remains...