Pathophysiology and Treatment of Non-motor Dysfunction in Amyotrophic Lateral Sclerosis
Abstract
Amyotrophic lateral sclerosis is a progressive and fatal neurodegenerative disease typically presenting with bulbar or limb weakness. There is increasing evidence that amyotrophic lateral sclerosis is a multisystem disease with early and frequent impacts on cognition, behaviour, sleep, pain and fatigue. Dysfunction of normal physiological and metabolic processes also appears common. Evidence from pre-symptomatic studies and large epidemiological...
Paper Details
Title
Pathophysiology and Treatment of Non-motor Dysfunction in Amyotrophic Lateral Sclerosis
Published Date
May 1, 2021
Journal
Volume
35
Issue
5
Pages
483 - 505
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Notes
History