Surface chemical modification of poly(phthalazinone ether nitrile ketone) through rhBMP-2 and antimicrobial peptide conjugation for enhanced osteogenic and antibacterial activities in vitro and in vivo

Failure of poly(aryl ether ketone) (PAEK) bone implants results mainly from poor osteogenesis and bacterial infection. One promising strategy for enhancing osteointegration involves developing a bioactive surface of PAEK implants through chemical modification. Poly(phthalazinone ether nitrile ketone) (PPENK) is considered a potential PAEK bone implant because it possesses mechanical properties similar to those of natural bone and its cyano group...