Establishment and characterization of a human embryonic stem cell line carrying a heterozygous GATA4T280M mutation
Abstract
Heterozygous T280M mutation in the GATA4 gene, encoding GATA binding protein 4, was recently identified in patients with congenital heart disease (CHD). Here, a human embryonic stem cell line carrying a heterozygous GATA4T280M mutation was generated by using the CRISPR/Cas9 and piggyBac technologies. This GATA4T280M cell line remains normal morphology, pluripotency and karyotype, and could differentiate into all three germ layers both in vivo...
Paper Details
Title
Establishment and characterization of a human embryonic stem cell line carrying a heterozygous GATA4T280M mutation
Published Date
May 1, 2021
Journal
Volume
53
Pages
102393 - 102393
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