Metabolic risk factors, genetic predisposition, and risk of severe liver disease in Chinese: a prospective study of 0.5 million people

Metabolic risk factors have been shown to be associated with severe liver disease (SLD) in Chinese populations. However, there is limited evidence on the combined impact of these factors, or the genetic variants associated with SLD.We examined the associations of combined metabolic risk factors with risks of SLD, both overall and by genetic predisposition to SLD.The study population involved 486,828 participants of the prospective China Kadoorie...