SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis
Abstract
•SPARC down-modulation is a necessary step toward autoimmunity and rheumatoid arthritis•SPARC controls neutrophil clearance regulating “don't-eat-me” signals and inflammation•Neutrophils escaping macrophage scavenging are source of antigens for dendritic cells The secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein with unexpected immunosuppressive function in myeloid cells. We investigated the role of SPARC in...
Paper Details
Title
SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis
Published Date
Jun 1, 2021
Journal
Volume
24
Issue
6
Pages
102510 - 102510
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