Comment on Piccinini and Bergman. The Measurement of Insulin Clearance. Diabetes Care 2020;43:2296–2302

We read with interest the review by Piccinini and Bergman (1) that 1 ) argues for superiority of the Polidori-Bergman model or peripheral-portal infusion technique to estimate the metabolic clearance rate of insulin (MCR-I) over other methods, and 2 ) hypothesizes that reduced MCR-I causes type 2 diabetes (T2D). Obviously, the peripheral-portal infusion approach is not feasible in humans. The Polidori-Bergman model allows one to estimate the...