Neutralizing anti–IL-1 receptor antagonist autoantibodies induce inflammatory and fibrotic mediators in IgG4-related disease

IgG4-related disease (IgG4-RD) is a fibroinflammatory condition involving loss of B-cell tolerance and production of autoantibodies. However, the relevant targets and role of these aberrant humoral immune responses are not defined.Our aim was to identify novel autoantibodies and autoantigen targets that promote pathogenic responses in IgG4-RD.We sequenced plasmablast antibody repertoires in patients with IgG4-RD. Representative mAbs were...