Evaluation of the potential of total proanthocyanidin content in feces as an intake biomarker

Published on Jul 1, 2021in Food Research International4.972
· DOI :10.1016/J.FOODRES.2021.110390
Cristina Magdaleno-Tapia (CSIC: Spanish National Research Council), Paola Quifer-Rada12
Estimated H-index: 12
+ 5 AuthorsJara Pérez-Jiménez (University of Barcelona)
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Abstract
Abstract Due to the health benefits associated with proanthocyanidins (PAs), it is useful to identify dietary PA biomarkers that can be determined by simple methods. Since increased levels of circulating PA metabolites are associated with increased fecal PA content, this study explores the spectrophotometric measurement of fecal PA content and its use as a biomarker of PA intake. To this end, fecal PA content was measured using an adaptation of Porter’s spectrophotometric method in samples from a preclinical study and an observational study. In the former, excretion of 250–400 mg PA polymer equivalents/100 g feces was observed during supplementation and the day after, together with a significant association (p
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