Evaluation of the potential of total proanthocyanidin content in feces as an intake biomarker

Published on Jul 1, 2021in Food Research International4.972
· DOI :10.1016/J.FOODRES.2021.110390
Cristina Magdaleno-Tapia (CSIC: Spanish National Research Council), Paola Quifer-Rada12
Estimated H-index: 12
+ 5 AuthorsJara Pérez-Jiménez (University of Barcelona)
Abstract Due to the health benefits associated with proanthocyanidins (PAs), it is useful to identify dietary PA biomarkers that can be determined by simple methods. Since increased levels of circulating PA metabolites are associated with increased fecal PA content, this study explores the spectrophotometric measurement of fecal PA content and its use as a biomarker of PA intake. To this end, fecal PA content was measured using an adaptation of Porter’s spectrophotometric method in samples from a preclinical study and an observational study. In the former, excretion of 250–400 mg PA polymer equivalents/100 g feces was observed during supplementation and the day after, together with a significant association (p
Last. Begoña BartoloméH-Index: 64
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There are some studies that suggest that moderate consumption of wine, as part of a healthy and balanced diet, has a favourable effect on intestinal health. This study evaluates the effect of moderate wine consumption on faecal water (FW) cytotoxicity as a parameter of gut health. To that end, faecal samples before and after a red wine intervention study (250 mL of wine/day, 4 weeks) in healthy volunteers (n = 8) and in a parallel control group (n = 3) were collected and assayed for in vitro FW ...
#1Leticia Lacalle-Bergeron (James I University)H-Index: 3
#2Tania Portolés (James I University)H-Index: 32
Last. Dolores Corella (University of Valencia)H-Index: 98
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A major problem with dietary assessments is their subjective nature. Untargeted metabolomics and new technologies can shed light on this issue and provide a more complete picture of dietary intake by measuring the profile of metabolites in biological samples. Oranges are one of the most consumed fruits in the world, and therefore one of the most studied for their properties. The aim of this work was the application of untargeted metabolomics approach with the novel combination of ion mobility se...
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Purpose In this study, we aimed to study the correlation between acute and habitual intakes of flavonols, their main food sources and their 24-h urinary concentrations in an European population.
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Last. Milagros Sánchez-PrietoH-Index: 2
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In the present study, the aim was to investigate the correlation between the acute and habitual dietary intake of flavanones, their main food sources and the concentrations of aglycones naringenin and hesperetin in 24 h urine in a European population. A 24-h dietary recall (24-HDR) and a 24-h urine sample were collected the same day from a subsample of 475 people from four different countries of the European Prospective Investigation into Cancer and Nutrition study. Acute and habitual dietary da...
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#1Pedro Mena (University of Parma)H-Index: 37
#2Iziar A. Ludwig (University of Parma)H-Index: 21
Last. Daniele Del Rio (University of Parma)H-Index: 62
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Purpose There is much information on the bioavailability of (poly)phenolic compounds following acute intake of various foods. However, there are only limited data on the effects of repeated and combined exposure to specific (poly)phenol food sources and the inter-individual variability in their bioavailability. This study evaluated the combined urinary excretion of (poly)phenols from green tea and coffee following daily consumption by healthy subjects in free-living conditions. The inter-individ...
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#1Britt Burton-Freeman (IIT: Illinois Institute of Technology)H-Index: 31
#2Michał Brzeziński (IIT: Illinois Institute of Technology)H-Index: 6
Last. Indika Edirisinghe (IIT: Illinois Institute of Technology)H-Index: 29
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Type 2 diabetes mellitus (T2DM) is the most common form of DM and its prevalence is increasing worldwide. Because it is a progressive disease, prevention, early detection and disease course modification are possible. Diet plays a critical role in reducing T2DM risk. Therapeutic dietary approaches routinely recommend diets high in plant foods (i.e., vegetables, fruits, whole-grains). In addition to essential micronutrients and fiber, plant-based diets contain a wide-variety of polyphenols, specif...
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#1Ryan C. Barnes (A&M: Texas A&M University)H-Index: 8
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SCOPE: This human clinical pilot trial investigated pharmacokinetics of gallotannin-metabolites and modulation of intestinal microbiota in healthy lean and obese individuals after 6 weeks of daily mango consumption. METHODS AND RESULTS: Participants are divided into three groups: Lean Mango (LM: n = 12; BMI = 22.9 kg m-2 ), Obese Mango (OM: n = 9; BMI = 34.6 kg m-2 ), and Lean Control (LC: n = 11; BMI = 22.1 kg m-2 ). LM and OM consumed 400 g of mango per day for 6 weeks. LC consumed mango only ...
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#1Adrián Cortés-Martín (CSIC: Spanish National Research Council)H-Index: 5
#2María V. Selma (CSIC: Spanish National Research Council)H-Index: 39
Last. Rocío García-Villalba (CSIC: Spanish National Research Council)H-Index: 36
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SCOPE: The stratification of individuals according to their gut microbiota metabotypes is crucial to understand the polyphenols health effects as reported for isoflavones and ellagitannins. To date, the existence of human gut microbiota metabotypes associated with proanthocyanidins (PAs) catabolism remains unclear. METHODS & RESULTS: Sixty-eight healthy volunteers (40 adolescents and 28 adults) consumed a mixture of walnuts, almonds, and hazelnuts for 3 days, providing 163.65 ± 11.74 mg of PAs. ...
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#1Gema Pereira-CaroH-Index: 25
Last. Alan Crozier (UC Davis: University of California, Davis)H-Index: 103
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Abstract This study developed, optimized and validated an ultra-high-performance liquid chromatography–high-resolution mass spectrometry (UHPLC-HRMS) method to identify and quantify metabolites and microbial-derived catabolites in urine, plasma and feces of rats following ingestion of 50 mg of a red wine proanthocyanidin-rich extract. The method was validated for specificity, linearity, limit of detection (LD) and quantification (LQ), intra-day and inter-day precision, recovery and matrix effect...
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Cited By0
#1Yue Hu (CWNU: China West Normal University)H-Index: 2
#2Yu-Cong Fan (CWNU: China West Normal University)
Last. Zhengjun Cheng (CWNU: China West Normal University)H-Index: 6
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Abstract null null By simultaneously regulating the photoluminescence of alloy Au/Ag nanoclusters (NCs) and thiamine (VB1) through MnO2 nanosheets (MnO2 NS), a novel ratiometric fluorescent probe (RF-probe) was established for sensitively and selectively monitoring proanthocyanidins (PAs). The introduction of Ag (I) ions could enhance significantly the quantum yields (QYs, 11.1%) of AuNCs based on the synthetic method of UVI (UV irradiation) combined with MWH (microwave heating). MnO2 NS could q...