Effect of suramin on urinary excretion of diabetes-induced glomerular and tubular injury parameters in rats

Volume: 139, Pages: 111683 - 111683
Published: Jul 1, 2021
Abstract
Diabetes mellitus causes changes in metabolism of extracellular nucleotides acting through P2 receptors (P2Rs). This affects renal function and may lead to glomerular and tubular disturbances. We measured urinary excretion of nucleotides (ATP, ADP, AMP, UTP, UDP, UMP) in streptozotocin-induced diabetic rats (65 mg/kg, i.p., day 0) and the effects of P2Rs’ blockade by suramin (10 mg/kg, i.p., days +7, +14) on glomerular P2×7R expression and...
Paper Details
Title
Effect of suramin on urinary excretion of diabetes-induced glomerular and tubular injury parameters in rats
Published Date
Jul 1, 2021
Journal
Volume
139
Pages
111683 - 111683
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