Tutorial on Biostatistics: Receiver-Operating Characteristic (ROC) Analysis for Correlated Eye Data

To demonstrate methods for receiver-operating characteristic (ROC) analysis of correlated eye data.We applied the Obuchowski's nonparametric approach and cluster bootstrap for estimating and comparing the area under ROC curve (AUC) between different sets of predictors to three datasets with varying inter-eye correlation.In an optic neuritis (ON) study of 152 eyes (80 patients), the AUC of optical coherence tomography retinal nerve fiber layer...