Association between waiting time for radiotherapy initiation and disease progression among women with cervical cancer in Addis Ababa, Ethiopia.

Published on Sep 15, 2021in International Journal of Cancer5.145
· DOI :10.1002/IJC.33689
Nebiyu Dereje4
Estimated H-index: 4
(AAU: Addis Ababa University),
Adamu Addissie14
Estimated H-index: 14
(AAU: Addis Ababa University)
+ 4 AuthorsAhmedin Jemal139
Estimated H-index: 139
(ACS: American Cancer Society)
Sources
Abstract
There is shortage of radiotherapy machines in low-income countries, including Ethiopia. Data on adverse effects of this on cancer outcomes are limited, however. Herein, we examined the extent of waiting time for radiotherapy and its association with disease progression based on a prospective cohort study of women diagnosed with stage IA-IVA cervical cancer in Addis Ababa and who were scheduled to receive radiotherapy at Tikur Anbessa Specialized Hospital, the only hospital that provides radiotherapy services in the country. Association was examined using Multivariable mixed effects logistic regression model. Among the 178 women with cervical cancer scheduled for receipt of radiotherapy and with vital status information, 16 deceased (9.0%) while waiting for radiotherapy. For the remaining 162 women who initiated radiotherapy, the median treatment waiting period was 137 days (IQR =60-234 days), with 74.1% of women waiting for >60 days. Tumor progressed to higher stage for 44.4% of these women. Compared with those women who initiated radiotherapy ≤60 days following diagnostic confirmation, the odds of tumor progression to higher stage was 3-times higher in those women who initiated radiotherapy between 120-179 days (aOR =3.30, 95%CI: 1.18-9.27) and ≥180 days (aOR =3.06, 95%CI: 1.24-7.52). Waiting period for receipt of radiotherapy among women with cervical cancer is exceedingly long in Addis Ababa, and it is associated with disease progression to higher stages. These findings reinforce the need to expand radiotherapy infrastructure in order to mitigate the undue high burden of the disease in Ethiopia and other parts of Africa.
References22
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#1Nebiyu Dereje (AAU: Addis Ababa University)H-Index: 4
#2Alem GebremariamH-Index: 11
Last. Ahmedin Jemal (ACS: American Cancer Society)H-Index: 139
view all 9 authors...
Objective To describe the patterns and factors associated with advanced stage at diagnosis of cervical cancer among Addis Ababa residents, Ethiopia. Design A population-based cross-sectional study. Setting Seven major hospitals or diagnostic facilities in Addis Ababa, Ethiopia. Participants All histopathology-confirmed patients with incident cervical cancer diagnosed from 1 January 2017 to 30 June 2018 among Addis Ababa residents. Outcome measures The proportion of patients with cervical cancer ...
2 CitationsSource
#2Sunday Adeyemi Adewuyi (ABU: Ahmadu Bello University)H-Index: 4
Last. Rasaaq OyesegunH-Index: 2
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Background: Access and availability of radiotherapy treatment is limited in most low- and middle-income countries, which leads to long waiting times and poor clinical outcomes. The aim of our study is to determine the magnitude of waiting times for radiotherapy in a resource-limited setting. Methods: This is a retrospective cohort study of patients with the five most commonly treated cancers managed with radiotherapy between 2010 and 2014. Data includes diagnosis, patients' demographics and trea...
1 CitationsSource
#1Nebiyu Dereje (AAU: Addis Ababa University)H-Index: 4
#2Adamu Addissie (AAU: Addis Ababa University)H-Index: 14
Last. Ahmedin Jemal (ACS: American Cancer Society)H-Index: 139
view all 8 authors...
PURPOSEA substantial proportion of cervical cancers are diagnosed at advanced stage in Ethiopia. Therefore, the aim of this study was to determine the extent and predictors of delays in cervical ca...
7 CitationsSource
#1Brendan Healy (IAEA: International Atomic Energy Agency)H-Index: 6
#2M. BudanecH-Index: 1
Last. L. Tuntipumiamorn (MU: Mahidol University)H-Index: 1
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AbstractBackground: The IAEA recommends a quality assurance program in radiotherapy to ensure safe and effective treatments. In this study, radiotherapy departments were surveyed on their current p...
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#1Mulugeta Wassie (University of Gondar)H-Index: 1
#2Zeleke Argaw (College of Health Sciences, Bahrain)H-Index: 1
Last. Sezer Kisa (University of Oslo)H-Index: 18
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Cervical cancer is a cancer of uterine cervix caused mostly by sexually-acquired infection called Human papillomavirus (HPV. In developing region of the globe, fewer than 50% of women with cervical malignancy survive more than 5 years. Therefore, the objective of this study was to assess survival status and associated factors of death among cervical cancer patients attending at Tikur Anbesa Specialized Hospital (TASH), Ethiopia. Facility based retrospective cohort study was conducted from March ...
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#1Chao-Ping Chen (PRC: China Medical University (PRC))H-Index: 1
#2Pei-Tseng Kung (PRC: China Medical University (PRC))H-Index: 14
Last. Wen-Chen Tsai (PRC: China Medical University (PRC))H-Index: 24
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Objectives Despite the ease of health care access and the waiver of copayments for cancer patients, treatment is delayed in a small proportion of Taiwanese patients diagnosed with cervical cancer. In this study, we explored the relationship between the time interval from diagnosis to treatment and survival in cervical cancer patients. Material and methods The study was a retrospective population-based observational study conducted between 2004 and 2010. In Taiwan, 12,020 patients were newly diag...
12 CitationsSource
#1Jian Yang (Sichuan University)
#2Haoyang Cai (Sichuan University)H-Index: 7
Last. Ping Yang (Shihezi University)H-Index: 2
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: Cervical cancer is among the most frequent cancer types in women worldwide. Radiotherapy, including external beam radiation and brachytherapy, is one of the commonly used treatment options for cervical cancer. However, the adverse effects of radiation therapy on cervical cancer survival have been poorly investigated with inconclusive results. Therefore, the aim of this study was to determine the suitable radiotherapy modality according to patients' characteristics. A retrospective survival ana...
13 CitationsSource
#1Alem GebremariamH-Index: 11
#2Adamu Addissie (AAU: Addis Ababa University)H-Index: 14
Last. Ahmedin Jemal (ACS: American Cancer Society)H-Index: 139
view all 8 authors...
Introduction Cancer is an emerging public health problem in Ethiopia, with breast and cervical cancers accounting for over half of all newly diagnosed cancers in women. The majority of women with breast and cervical cancer are diagnosed at late stage of the disease and most patients do not receive care consistent with global standards. However, little is known about the health-seeking behaviours, barriers to early detection and treatment, patient-reported outcomes, financial burden and survival ...
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#1Werissaw Haileselassie (College of Health Sciences, Bahrain)H-Index: 2
#2Tefera Mulugeta (College of Health Sciences, Bahrain)H-Index: 1
Last. Wajana Lako Labisso (College of Health Sciences, Bahrain)H-Index: 2
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Background: Less attention is given to cancer treatment and control in Ethiopia. Methods: To investigate the challenges and opportunities facing cancer treatment services in Ethiopia. A purposive sampling technique was applied to recruit the study subjects from Black Lion Specialized Hospital Oncology Department. A semi-structured interview guide was used to investigate challenges and opportunities in oncology service in Ethiopia. Data was transcribed and coded by two independent coders and anal...
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#1I.F.d. Silva (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 1
#2Ilce Ferreira da Silva (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 5
Last. Rosalina Jorge Koifman (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 24
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PURPOSETo estimate treatment delays and associated factors among women diagnosed with cervical cancer who were treated at the main cancer center in Rio de Janeiro, Brazil.MATERIALS AND METHODSA retrospective cohort study was performed comprising 865 women newly diagnosed with cervical cancer between 2012 and 2014. Times from diagnosis to treatment initiation (less than or equal to 60 days) and from diagnosis to treatment ending (less than or equal to 120 days) were analyzed according to the Braz...
5 CitationsSource
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