Computational Tools to Assess the Functional Consequences of Rare and Noncoding Pharmacogenetic Variability

Interindividual differences in drug response are a common concern in both drug development and across layers of care. While genetics clearly influences drug response and toxicity of many drugs, a substantial fraction of the heritable pharmacological and toxicological variability remains unexplained by known genetic polymorphisms. In recent years, population‐scale sequencing projects have unveiled tens of thousands of coding and noncoding...