Cellular carbon stress is a mediator of obesity-associated osteoarthritis development

Objective‘Carbon stress’ is a newly found mechanism that links obesity and dysregulated metabolism. It is defined as the cellular accumulation of metabolites during obesity post-translationally modifying metabolic proteins and decreasing their enzymatic activity. The objective of this study was to investigate if ‘carbon stress’ also occurs in cartilage and contributes to obesity associated OA development.MethodsWe histologically evaluated for OA...