Developmental Origins of Delayed Adult Immune Response: The AhR Connection.

Published on May 12, 2021in Environmental Health Perspectives9.031
· DOI :10.1289/EHP9275
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Abstract
References12
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Background: Early life environmental exposures can have lasting effects on the function of the immune system and contribute to disease later in life. Epidemiological studies have linked early life ...
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#1Clara Amalie Gade Timmermann (University of Southern Denmark)H-Index: 9
#2Kristoffer Jarlov Jensen (DTU: Technical University of Denmark)H-Index: 12
Last. Ane Bærent Fisker (SSI: Statens Serum Institut)H-Index: 23
view all 8 authors...
Background: Perfluoroalkyl substances (PFAS) are a group of widely used persistent chemicals with suspected immunotoxic effects. Objectives: The present study aimed to examine the association betwe...
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#1Christina M. Post (UR: University of Rochester)H-Index: 3
#2Lisbeth A. Boule (UR: University of Rochester)H-Index: 9
Last. B. Paige Lawrence (UR: University of Rochester)H-Index: 31
view all 6 authors...
Summary Recent studies have linked health fates of children to environmental exposures of their great grandparents. However, few studies have considered whether ancestral exposures influence immune function across generations. Here, we report transgenerational inheritance of altered T cell responses resulting from maternal (F0) exposure to the aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Since F0 exposure to TCDD has been linked to transgenerational transmission o...
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#1Catherine G. Burke (UR: University of Rochester)H-Index: 4
#2Jason R. Myers (UR: University of Rochester)H-Index: 18
Last. B. Paige Lawrence (UR: University of Rochester)H-Index: 31
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Early life environmental exposures drive lasting changes to the function of the immune system and can contribute to disease later in life. One of the ways environmental factors act is through cellular receptors. The aryl hydrocarbon receptor (AHR) is expressed by immune cells and binds numerous xenobiotics. Early life exposure to chemicals that bind the AHR impairs CD4+ T cell responses to influenza A virus (IAV) infection in adulthood. However, the cellular mechanisms that underlie these durabl...
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#1Liza Bronner Murrison (University of Cincinnati Academic Health Center)H-Index: 4
#2Eric B. Brandt (Cincinnati Children's Hospital Medical Center)H-Index: 37
Last. Gurjit K. Khurana Hershey (University of Cincinnati Academic Health Center)H-Index: 66
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: Environmental exposures interplay with human host factors to promote the development and progression of allergic diseases. The worldwide prevalence of allergic disease is rising as a result of complex gene-environment interactions that shape the immune system and host response. Research shows an association between the rise of allergic diseases and increasingly modern Westernized lifestyles, which are characterized by increased urbanization, time spent indoors, and antibiotic usage. These envi...
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#1Veit Rothhammer (Brigham and Women's Hospital)H-Index: 22
#2Francisco J. Quintana (Brigham and Women's Hospital)H-Index: 74
The environment, diet, microbiota and body’s metabolism shape complex biological processes in health and disease. However, our understanding of the molecular pathways involved in these processes is still limited. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that integrates environmental, dietary, microbial and metabolic cues to control complex transcriptional programmes in a ligand-specific, cell-type-specific and context-specific manner. In this Review, we summ...
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: Epidemiological and experimental studies have shown that the peri-conception period, pregnancy, and infancy are windows of particular sensibility to environmental clues which influence lifelong trajectories across health and disease. Nutrition, stress, and toxins induce epigenetic marks that control long-term gene expression patterns and can be transmitted transgenerationally. Chronic diseases of adulthood such as hypertension, diabetes, and obesity thus have early, developmental origins in th...
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#1Sonia Mulero-Navarro (University of Extremadura)H-Index: 18
#2Pedro M. Fernandez-Salguero (University of Extremadura)H-Index: 60
Traditionally considered as a critical intermediate in the toxic and carcinogenic response to dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD), the Aryl hydrocarbon/Dioxin receptor (AhR) has proven to be also an important regulator of cell physiology and organ homeostasis. AhR has become an interesting and actual area of research mainly boosted by a significant number of recent studies analyzing its contribution to the proper functioning of the immune, hepatic, cardiovascular, vascular and rep...
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Potentially carcinogenic compounds may cause cancer through direct DNA damage or through indirect cellular or physiological effects. To study possible carcinogens, the fields of endocrinology, genetics, epigenetics, medicine, environmental health, toxicology, pharmacology and oncology must be considered. Disruptive chemicals may also contribute to multiple stages of tumor development through effects on the tumor microenvironment. In turn, the tumor microenvironment consists of a complex interact...
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#1Lisbeth A. Boule (UR: University of Rochester)H-Index: 9
#2Bethany WinansH-Index: 9
Last. B. Paige LawrenceH-Index: 31
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Background: Epidemiological and animal studies indicate that maternal exposure to pollutants that bind the aryl hydrocarbon receptor (AhR) correlates with poorer ability to combat respiratory infec...
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