Does synaptic hypometabolism or synaptic dysfunction, originate cognitive loss? Analysis of the evidence

Elderly persons with currently normal cognition who have cerebral hypometabolism as shown by low uptake of 18 fluorine‐fluorodeoxyglucose ( 18 F‐FDG), are at risk of future loss of cognition and, thus, of future Alzheimer's dementia (AD). Reduction of either 18 F‐FDG or cognition is assumed to reflect synaptic dysfunction, since synapses account for the majority of glucose use by the brain and cognition depends upon accurate synaptic function....